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Research and development in organic synthesis

Research and Development Analytical Chemistry

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Research and Development Analytical Chemistry

Preparation of samples on lab scale (10 milligrams-100 grams):

  • Standards of non commercially available compounds
  • Scaffolds for combinatorial libraries
  • APIís impurities
  • APIís metabolites
  • Enantiomerically pure compounds
  • Stable isotopes (D, 13C, 15N, 18O)

Development of synthesis methods

  • Experimental check of the methods of synthesis provided by the customers
  • Experimental design of new methods starting from the bibliographical search
  • Synthesis on lab scale (1-10 grams)
  • Definition of the analytical methods both for the IPCs and for the final product
  • Preparation of the standards of the intermediates and of the final product, complete of analytical characterization
  • Preparation of the technical report, with raw data included
  • Development of the method of synthesis in agreement with the request from the customer
  • Experimental test of the method in kilolab (500 g-1 kg)
  • Technology transfer and assistance during the production of the pilot batches
  • Assistance in search of other industrial partners

 

Isolation and characterization of impurities

  • Experimental study and development of methods of purification by:

Chromatography

Crystallization

Extraction

All the samples supplied by Chimete are provided with the certificate of analysis, with raw data included.

Based on the customers request and according to the existing CdA, the technical reports regarding the activities are submitted.

 

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Chimete srl

Chimete srl